Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine
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چکیده
منابع مشابه
Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine.
Polyamine biosynthesis in intact cells can be exquisitely controlled with exogenous polyamines through the regulation of rate-limiting biosynthetic enzymes, particularly ornithine decarboxylase (ODC). In an attempt to exploit this phenomenon as an antiproliferative strategy, certain polyamine analogues have been identified [Porter, Cavanaugh, Stolowich, Ganis, Kelly & Bergeron (1985) Cancer Res...
متن کاملAberrant Regulation of Ornithine Decarboxylase by Serum, Putrescine, and Spermidine in Cytomegalovirustransformed Human Cells1
Regulation of omnithine decarboxylase (ODC) activity by serum and pohyamines in cytomegalovirus (CMV)-infected cells and in earlyand late-passage CMV-transfommed hu man cells was studied. Exposure of early-passage growth arrested CMV-tnansfommed human cells to fresh medium containing 10% serum resulted in dramatic but short-lived elevations in ODC activity; maximal activity was approxi mately 4...
متن کاملAberrant regulation of ornithine decarboxylase by serum, putrescine, and spermidine in cytomegalovirus-transformed human cells.
Regulation of omnithine decarboxylase (ODC) activity by serum and pohyamines in cytomegalovirus (CMV)-infected cells and in earlyand late-passage CMV-transfommed hu man cells was studied. Exposure of early-passage growth arrested CMV-tnansfommed human cells to fresh medium containing 10% serum resulted in dramatic but short-lived elevations in ODC activity; maximal activity was approxi mately 4...
متن کاملControl of ornithine decarboxylase activity in stimulated human lymphocytes by putrescine and spermidine.
Ornithine decarboxylase activity in extracts of phytohaemagglutinin-stimulated human lymphocytes is rapidly and extensively inhibited by additions of micromolar concentrations of putrescine or spermidine to the culture medium. This inhibition is not due to feedback inhibition of the enzyme by putrescine, spermidine or their metabolites. Inhibition is dependent on the continuation of protein syn...
متن کاملDistinct roles of putrescine and spermidine in the regulation of ornithine decarboxylase in Neurospora crassa.
We wished to identify metabolic signals governing changes in ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in Neurospora crassa. By manipulations of the ornithine supply and by the use of inhibitors of the polyamine pathway, we found that spermidine negatively governs formation of active ornithine decarboxylase and that putrescine promotes inactivation of the enzyme....
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1987
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2420433